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Hypothyroidism (underactive thyroid): The thyroid gland is unable to produce thyroid hormone in sufficient quantities, which can cause a host of symptoms, including fatigue, muscle weakness, increased cold sensitivity, constipation, dry skin, weight gain, puffy face, hoarseness, elevated blood cholesterol, muscle aches, swollen joints, thinning hair, depression, impaired memory, slowed heart rate, and heavier than normal or irregular menstrual periods

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This is distinct from performance anxiety or relationship factors

Researchers are developing advanced delivery systems like nanoparticles for better results